Artikler – peer reviewed (2009 – 2017)

Aggerholm-Pedersen N, Bærentzen S, Holmberg Jørgensen JP, Safwat A. A rare case of CD30(+), radiation-induced cutaneous angiosarcoma misdiagnosed as T-cell lymphoma. J Clin Oncol 2011 May 1;29(13):e362-4.

Aggerholm-Pedersen N, Demuth C, Safwat A, Meldgaard P, Kassem M, Sandahl Sorensen B. Dasatinib and Doxorubicin Treatment of Sarcoma Initiating Cells: A Possible New Treatment Strategy. Stem Cells Int 2016;2016:9601493.

Aggerholm-Pedersen N, Maretty-Kongstad K, Keller J, Baerentzen S, Safwat A. The Prognostic Value of Serum Biomarkers in Localized Bone Sarcoma. Transl Oncol 2016 Aug;9(4):322-8.

Aggerholm-Pedersen N, Maretty-Nielsen K, Keller J, Baerentzen S, Safwat A. Comorbidity in adult bone sarcoma patients: a population-based cohort study. Sarcoma 2014;2014:690316.

Aggerholm-Pedersen N, Maretty-Nielsen K, Keller J, Baerentzen S, Schrøder H, Jørgensen PH, Hansen BH, Nielsen OS, Safwat A. The importance of standardized treatment in high-grade osteosarcoma: 30 years of experience from a hospital-based database. Acta Oncol 2015 Jan;54(1):17-24.

Aggerholm-Pedersen N, Rasmussen P, Dybdahl H, Rossen P, Nielsen OS, Safwat A. Serum Natrium Determines Outcome of Treatment of Advanced GIST with Imatinib: A Retrospective Study of 80 Patients from a Single Institution. ISRN Oncol 2011;2011:523915.

Aggerholm-Pedersen N, Safwat A, Bærentzen S, Nordsmark M, Nielsen OS, Alsner J, Sørensen BS. The importance of reference gene analysis of formalin-fixed, paraffin-embedded samples from sarcoma patients – an often underestimated problem. Transl Oncol 2014 Dec;7(6):687-93.

Aggerholm-Pedersen N, Sørensen BS, Overgaard J, Toustrup K, Baerentzen S, Nielsen OS, Maretty-Kongstad K, Nordsmark M, Alsner J, Safwat A. A prognostic profile of hypoxia-induced genes for localised high-grade soft tissue sarcoma. Br J Cancer 2016 Oct 25;115(9):1096-1104.

Andersen KF, Albrecht-Beste E, Berthelsen AK, Loft A. Angiosarcoma of the scalp: metastatic pulmonary cystic lesions initially misinterpreted as benign findings on 18F-FDG PET/CT. Diagnostics 2015 Dec 22;6(1).

Andersen KF, Fuglø HM, Rasmussen SH, Petersen MM, Loft A. Semi-quantitative calculations of primary tumor metabolic activity using F-18 FDG PET/CT as a predictor of survival in 92 patients with high-grade bone or soft tissue sarcoma. Medicine 2015 Jul;94(28):e1142.

Andersen KF, Fuglø HM, Rasmussen SH, Petersen MM, Loft A. Volume-based F-18 FDG PET/CT imaging markers provide supplemental prognostic information to histologic grading in patients with high-grade bone or soft tissue sarcoma. Medicine 2015 Dec;94(51):e2319.

Andersen KF, Jensen KE, Loft A. PET/MR imaging in musculoskeletal disorders. PET Clin 2016 Oct;11(4):453-63.

Andersen MR, Petersen MM. Adaptive Bone Remodeling of the Femoral Bone After Tumor Resection Arthroplasty With an Uncemented Proximally Hydroxyapatite-Coated Stem. J Clin Densitom 2016 Apr-Jun;19(2):202-7.

Andersen NB, Boysen AK, Rossen PB, Lücke AO, Safwat AA. Bilateral avascular necrosis of the femoral head following treatment of Ewing’s sarcoma. Acta Oncol 2016 Jun;55(6):792-5.

Burns JS, Safwat A, Grisendi G, Kassem M, Dominici M. Sarcomas as a mise en abyme of mesenchymal stem cells: exploiting interrelationships for cell mediated anticancer therapy. Cancer Lett 2012 Dec 1;325(1):1-10.

D’Andrea FP, Horsman MR, Kassem M, Overgaard J, Safwat A. Tumourigenicity and radiation resistance of mesenchymal stem cells. Acta Oncol 2012 May;51(5):669-79.

D’Andrea FP, Safwat A, Burns JS, Kassem M, Horsman MR, Overgaard J. Tumour microenvironment and radiation response in sarcomas originating from tumourigenic human mesenchymal stem cells. Int J Radiat Biol 2012 Jun;88(6):457-65.

D’Andrea FP, Safwat A, Kassem M, Gautier L, Overgaard J, Horsman MR. Cancer stem cell overexpression of nicotinamide N-methyltransferase enhances cellular radiation resistance. Radiother Oncol 2011 Jun;99(3):373-8.

Dyrop HB, Vedsted P, Rædkjær M, Safwat A, Keller J. Routes to Diagnosis for Suspected Sarcoma: The Impact of Symptoms and Clinical Findings on the Diagnostic Process. Sarcoma 2016;2016:8639272.

Dyrop HB, Safwat A, Vedsted P, Maretty-Kongstad K, Hansen BH, Jørgensen PH, Baad-Hansen T, Keller J. Characteristics of 64 sarcoma patients referred to a sarcoma center after unplanned excision. J Surg Oncol 2016 Feb;113(2):235-9.

Dyrop HB, Safwat A, Vedsted P, Maretty-Nielsen K, Hansen BH, Jørgensen PH, Baad-Hansen T, Bünger C, Keller J. Cancer Patient Pathways shortens waiting times and accelerates the diagnostic process of suspected sarcoma patients in Denmark. Health Policy 2013 Nov;113(1-2):110-7.

Dyrop HB, Vedsted P, Safwat A, Maretty-Nielsen K, Hansen BH, Jørgensen PH, Baad-Hansen T, Keller J. Alarm symptoms of soft-tissue and bone sarcoma in patients referred to a specialist center. Acta Orthop 2014 Dec;85(6):657-62.

Dyrop HB, Vedsted P, Rædkjær M, Safwat A, Keller J. Imaging investigations before referral to a sarcoma center delay the final diagnosis of musculoskeletal sarcoma. Acta Orthop 2017 Apr;88(2):211-216.

Forsberg JA, Wedin R, Bauer HC, Hansen BH, Laitinen M, Trovik CS, Keller JØ, Boland PJ, Healey JH. External validation of the Bayesian Estimated Tools for Survival (BETS) models in patients with surgically treated skeletal metastases. BMC Cancer 2012 Oct 25;12:493.

Fuglø HM, Jørgensen SM, Loft A, Hovgaard D, Petersen MM. The diagnostic and prognostic value of ¹⁸F-FDG PET/CT in the initial assessment of high-grade bone and soft tissue sarcoma. A retrospective study of 89 patients. Eur J Nucl Med Mol Imaging 2012 Sep;39(9):1416-24.

Fuglø HM, Maretty-Nielsen K, Hovgaard D, Keller JØ, Safwat AA, Petersen MM. Metastatic pattern, local relapse, and survival of patients with myxoid liposarcoma: a retrospective study of 45 patients. Sarcoma 2013;2013:548628.

Hansen BH, Keller J, Laitinen, Berg P, Skjeldal S, Trovik C, Nilsson J, Walloe A, Wedin R. The Scandinavian Sarcoma Group Skeletal Metastasis Registry: Functional outcome and pain after surgery for bone metastases in the pelvis and extremities. Acta Orthop Scand 2009 Apr;80(Suppl 334):85-90.

Harving ML, Christensen LH, Ringsholt M, Lausten GS, Petersen MM. YKL-40 expression in soft-tissue sarcomas and atypical lipomatous tumors. An immunohistochemical study of 49 tumors. Acta Orthop. 2014 Apr;85(2):195-200.

Hettwer WH, Horstmann PF, Grum-Schwensen TA, Petersen MM. Persistent wound drainage after tumor resection and endoprosthetic reconstruction of the proximal femur. Open Orthop J 2014 Dec 29;8:475-81.

Holm M, Aggerholm-Pedersen N, Mele M, Jørgensen P, Baerentzen S, Safwat A. Primary breast sarcoma: A retrospective study over 35 years from a single institution. Acta Oncol 2016 May;55(5):584-90.

Holm MP, Hjorthaug K, Bærentzen S, Safwat AA. Unsustained response to brentuximab as single agent therapy in a patient with CD30 positive angiosarcoma. Acta Oncol 2016;55(2):251-3.

Hovgaard TB, Nymark T, Skov O, Petersen MM. Follow-up after initial surgical treatment of soft tissue sarcomas in the extremities and trunk wall. Acta Oncol 2017 Jul;56(7):1004-1012.

Hygum K, Wulff CN, Harsløf T, Boysen AK, Rossen PB, Langdahl BL, Safwat AA. Hypercalcemia in metastatic GIST caused by systemic elevated calcitriol: a case report and review of the literature. BMC Cancer 2015 Oct 24;15:788.

Kollár A, Jones RL, Stacchiotti S, Gelderblom H, Guida M, Grignani G, Steeghs N, Safwat A, Katz D, Duffaud F, Sleijfer S, van der Graaf WT, Touati N, Litière S, Marreaud S, Gronchi A, Kasper B. Pazopanib in advanced vascular sarcomas: an EORTC Soft Tissue and Bone Sarcoma Group (STBSG) retrospective analysis. Acta Oncol 2017 Jan;56(1):88-92.

Knudsen M, Riishede A, Lücke A, Gelineck J, Keller J, Baad-Hansen T. Computed tomography-guided radiofrequency ablation is a safe and effective treatment of osteoid osteoma located outside the spine. Dan Med J 2015 May;62(5). pii: A5059.

Ladefoged CN, Hansen AE, Andersen KF, Loft A, Højgaard L, Kjær A, Andersen F. PET/MR imaging of sarcomas: effect of PET quantification by classification of tissue. EJNMMI Phys 2014 Jul;1(Suppl 1):A67.

Loft A, Jensen KE, Löfgren J, Daugaard S, Petersen MM. PET/MRI for Preoperative Planning in Patients with Soft Tissue Sarcoma: A Technical Report of Two Patients. Case Rep Med 2013;2013:791078.

Maretty-Nielsen K, Aggerholm-Pedersen N, Keller J, Safwat A, Baerentzen S, Pedersen AB. Population-based Aarhus Sarcoma Registry: validity, completeness of registration, and incidence of bone and soft tissue sarcomas in western Denmark. Clin Epidemiol 2013 Mar 6;5:45-56.

Maretty-Nielsen K, Aggerholm-Pedersen N, Keller J, Safwat A, Baerentzen S, Pedersen AB. Relative mortality in soft tissue sarcoma patients: a Danish population-based cohort study. BMC Cancer 2014 Sep 19;14:682.

Maretty-Nielsen K, Aggerholm-Pedersen N, Safwat A, Baerentzen S, Pedersen AB, Keller J. Prevalence and prognostic impact of comorbidity in soft tissue sarcoma: a population-based cohort study. Acta Oncol 2014 Sep;53(9):1188-96.

Maretty-Nielsen K, Aggerholm-Pedersen N, Safwat A, Jørgensen PH, Hansen BH, Baerentzen S, Pedersen AB, Keller J. Prognostic factors for local recurrence and mortality in adult soft tissue sarcoma of the extremities and trunk wall: a cohort study of 922 consecutive patients. Acta Orthop 2014 Jun;85(3):323-32.

Maretty-Nielsen K, Baerentzen S, Keller J, Dyrop HB, Safwat A. Low-Grade Fibromyxoid Sarcoma: Incidence, Treatment Strategy of Metastases, and Clinical Significance of the FUS Gene. Sarcoma 2013;2013:256280.

Marina NM, Smeland S, Bielack SS, Bernstein M, Jovic G, Krailo MD, Hook JM, Arndt C, van den Berg H, Brennan B, Brichard B, Brown KL, Butterfass-Bahloul T, Calaminus G, Daldrup-Link HE, Eriksson M, Gebhardt MC, Gelderblom H, Gerss J, Goldsby R, Goorin A, Gorlick R, Grier HE, Hale JP, Hall KS, Hardes J, Hawkins DS, Helmke K, Hogendoorn PC, Isakoff MS, Janeway KA, Jürgens H, Kager L, Kühne T, Lau CC, Leavey PJ, Lessnick SL, Mascarenhas L, Meyers PA, Mottl H, Nathrath M, Papai Z, Randall RL, Reichardt P, Renard M, Safwat AA, Schwartz CL, Stevens MC, Strauss SJ, Teot L, Werner M, Sydes MR, Whelan JS. Comparison of MAPIE versus MAP in patients with a poor response to preoperative chemotherapy for newly diagnosed high-grade osteosarcoma (EURAMOS-1): an open-label, international, randomised controlled trial. Lancet Oncol 2016 Oct;17(10):1396-1408.

PARITY Investigators. Prophylactic antibiotic regimens in tumour surgery (PARITY): a pilot multicentre randomised controlled trial. Bone Joint Res. 2015 Sep;4(9):154-62.

Petersen MM, Hovgaard D, Elberg JJ, Rechnitzer C, Daugaard S, Muhic A. Vascularized fibula grafts for reconstruction of bone defects after resection of bone sarcomas. Sarcoma 2010;2010:524721.

Riishede I, Ewertsen C, Carlsen J, Petersen MM, Jensen F, Nielsen MB. Strain Elastography for Prediction of Malignancy in Soft Tissue Tumours–Preliminary Results. Ultraschall Med 2015 Aug;36(4):369-74.

Saebye C, Fugloe HM, Nymark T, Safwat A, Petersen MM, Baad-Hansen T, Krarup-Hansen A, Keller J. Factors associated with reduced functional outcome and quality of life in patients having limb-sparing surgery for soft tissue sarcomas – a national multicenter study of 128 patients. Acta Oncol 2017 Feb;56(2):239-244.

Safwat A, Boysen A, Lücke A, Rossen P. Pazopanib in metastatic osteosarcoma: significant clinical response in three consecutive patients. Acta Oncol 2014 Oct;53(10):1451-4.

Schack LH, Mouritsen LS, Elowsson C, Krarup-Hansen A, Safwat A. The Danish experience with trabectedin treatment for metastatic sarcoma: Importance of hyponatremia. Acta Oncol 2015 Jan;54(1):34-40.

Sæbye C, Safwat A, Kaa AK, Pedersen NA, Keller J. Validation of a Danish version of the Toronto Extremity Salvage Score questionnaire for patients with sarcoma in the extremities. Dan Med J. 2014 Jan;61(1):A4734.

Sørensen MS, Gerds TA, Hindsø K, Petersen MM. Prediction of survival after surgery due to skeletal metastases in the extremities. Bone Joint J 2016 Feb;98-B(2):271-7.

Sørensen MS, Gregersen KG, Grum-Schwensen T, Hovgaard D, Petersen MM. Patient and implant survival following joint replacement because of metastatic bone disease. Acta Orthop 2013 Jun;84(3):301-6.

Sørensen MS, Hindsø K, Hovgaard TB, Petersen MM. Extent of Surgery Does Not Influence 30-Day Mortality in Surgery for Metastatic Bone Disease: An Observational Study of a Historical Cohort. Medicine 2016 Apr;95(15):e3354.

Thorn AP, Daugaard S, Christensen LH, Christensen IJ, Petersen MM. YKL-40 protein in osteosarcoma tumor tissue. APMIS 2016 Jun;124(6):453-61.

Ulrich LG. Benign leiomyoma or malignant sarcoma: the difficult differential diagnosis. Maturitas 2015 Mar;80(3):235-6.

Vitfell-Rasmussen J, Judson I, Safwat A, Jones RL, Rossen PB, Lind-Hansen M, Knoblauch P, Krarup-Hansen A. A Phase I/II Clinical Trial of Belinostat (PXD101) in Combination with Doxorubicin in Patients with Soft Tissue Sarcomas. Sarcoma 2016;2016:2090271.

Ph.d.- afhandlinger

Aggerholm-Pedersen N. The influence of hypoxia in soft tissue sarcoma: Molecular studies in clinical material. Aarhus University 2015.
Dyrop HB. From symptoms to diagnosis of sarcoma – revealing the diagnostic pathway. Aarhus University 2016.

Maretty-Nielsen K. Prognostic factors in soft tissue sarcoma: Population-based studies on comorbidity, biomarkers, and methodological aspects. Aarhus University 2014. Dan Med J. 2014 Nov;61(11):B4957.